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Moderate selenium doses (300–800 µg/day) have shown success in improving outcomes, while high-dose regimens (e.g., 3000–4000 µg/day) have produced inconsistent results, with limited impact on mortality or ICU length of stay [15,35]

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Most evidence suggests that glutathione molecules are relatively large, which makes it difficult for them to penetrate deep into the dermis and enter the systemic circulation in significant amounts